Link Between Smoking And Heart Disease? Home » Questions » Heart & Cardio » Link Between Smoking And Heart Disease? 0 Vote Up Vote Down Anonymous asked 8 years ago What’s the link between smoking and heart disease? 2 Answers 0 Vote Up Vote Down Dr Deepthi Satish Staff answered 8 years ago Hi Smoking is one of the major risk factor for heart disease. Regards Dr.Deepthi 0 Vote Up Vote Down Dr Himanshu Shekhar - Physician Staff answered 8 years ago Hi Smoking causes more cholesterol formation and hence more atherosclerosis of the cardiac blood circulations. And hence cardiac diseases and block. Thanks Dr.Himanshu Shekhar